Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models
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چکیده
منابع مشابه
Germline mutations in driver oncogenes and inherited lung cancer risk independent of smoking history.
Although the single most important risk factor for developing lung cancer is a personal history of cigarette smoking, it is well documented that there also exists inherited lung cancer risk that cannot entirely be accounted for by smoking patterns alone (1). Genome-wide association studies of patients with lung cancer have provided strong evidence for a susceptibility region in chromosome 15q25...
متن کاملMolecular Epidemiology of Lung Cancer Driver Mutations
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Purpose: The molecular epidemiology of most EGFR and KRAS mutations in lung cancer remains unclear. Experimental Design: We genotyped 3026 lung adenocarcinomas for the major EGFR (exon 19 deletions and L858R) and KRAS (G12, G13) mutations and examined correlations with demographic, cli...
متن کاملDriver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
Non-small cell lung cancer can exhibit driver oncogenes, including epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), that are possible targets for therapy. The prevalence of these rearranged driver oncogenes is influenced by race, smoking habits, and gender. Most data come from Caucasian and Asian populations. To our knowledge, there is no literature available about ...
متن کاملRelationship of driver oncogenes to long term pemetrexed response in non-small cell lung cancer
BACKGROUND Pemetrexed is approved in the treatment of advanced stage nonsquamous non-small-cell lung cancer (NSCLC). The length of response is variable, and we thus sought to identify which clinicopathologic characteristics are associated with long-term disease control with pemetrexed. PATIENTS AND METHODS Patients with metastatic NSCLC received pemetrexed (with or without bevacizumab) for 12...
متن کاملDriver and passenger mutations in cancer.
Next-generation sequencing has allowed identification of millions of somatic mutations and epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and epigenomes is distinguishing which genetic and epigenetic changes are drivers of cancer development. Frequency-based and function-based approaches have been developed to identify candidate drivers; we discuss the advant...
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ژورنال
عنوان ژورنال: ALTEX
سال: 2020
ISSN: 1868-596X
DOI: 10.14573/altex.1912131